Dapoxetine

While this medicine is easily available over the counter, you are strongly advised to consult a psychiatrist before beginning to use this medication. There is no conclusive evidence to suggest that dapoxetine has a significant impact on sperm quality or fertility. However, if you have concerns about how it might affect your reproductive health, it’s best to discuss them with your healthcare provider. The use of dapoxetine insteadof less costly off label SSRIs or local anaesthetics could create a costpressure which may have an impact on the local health economies which alreadyhave to identify savings. Theneeds of the population appear to be low as there are other availabletreatments which may be used, albeit in an off- label manner.

This pause allows the patient to acclimatize to the sensation and to condition himself to increased ejaculatory control. This technique helps the patient to heighten his awareness of sexual sensations. Unfortunately, many others have found that any initial success achieved by behavioral therapy was not maintained at 3-year follow-up (Sharlip 2005). MEDLINE and the proceedings of major international and regional scientific meetings during the period 1994–2010 were searched for publications or abstracts using the word dapoxetine in the title, abstract or keywords. This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase 1, 2 and 3 efficacy and safety studies and drug-interaction studies.

• In rapidly ejaculating rats, the density of Fos expressing cells in the hypothalamus, amygdala, and LPGi were significantly higher than in the normal and sluggish categories (92,93).
• It increases the time it takes to ejaculate and can improve the control over the ejaculation.
• Articles involving dapoxetine for the treatment of PE were identified, with priority given to systematic reviews, meta-analyses and integrated analyses, double-blind, randomized, placebo-controlled clinical trials (RCTs), and nonrandomized observational studies.
• It is limited to heterosexual men engaging in vaginal intercourse as there are few studies available on PE research in homosexual men or during other forms of sexual expression.
• Adequately powered randomized, controlled trials were considered the strongest form of evidence but all other articles were also considered.
• Caution should be exercised in patients with diseases of the cardiovascular system.

Dapoxetine – Uses, Contraindications, Drug Interactions, and Side Effects

Also, an aerosol formulation of lidocaine-prilocaine is effective in prolonging IELT and in improving sexual satisfaction in men with PE and their partners. The main drawback of topical anesthetics is their potential to cause a reduction in penile sensation and vaginal numbness in his partner. Chronic SSRI treatment for psychiatric conditions is known to predispose patients to withdrawal symptoms if medication is suspended abruptly Zajecka et al. 1991, 1997. The SSRI withdrawal syndrome is characterized by dizziness, headache, nausea, vomiting and diarrhoea and occasionally agitation, impaired concentration, vivid dreams, depersonalization, irritability and suicidal ideation Black et al. 2000; Ditto, 2003. The DESS comprises 43 possible withdrawal signs and symptoms, each rated and scored as new, old and worse, unchanged or improved or absent. There was a low incidence of SSRI withdrawal syndrome across treatment groups that was similar among patients who continued to take dapoxetine or placebo and those who switched to placebo during a 1-week withdrawal period.

Efficacy of Dapoxetine in the Treatment of Premature Ejaculation

In the International Study, the incidence of discontinuation syndrome was steroids 3.0%, 1.1% and 1.3% for those continuing to take dapoxetine 30 mg, 60 mg as needed and placebo respectively, and 3.3% for those who switched from dapoxetine 60 mg as needed to placebo Buvat et al. 2009. No subjects switching from dapoxetine 30 mg as needed to placebo in this study showed evidence of the discontinuation syndrome. Dapoxetine is the only SSRI for which these symptoms have been systematically evaluated in a PE population.

Getting the most from your treatment

Lots of research concerning the EP were designed incorrectly or errors were made methodological, which makes them not reliable enough. Dapoxetine should not be combined with MAO inhibitors or selective serotonin reuptake inhibitors, since a serotonin syndrome may develop. Treatment-emergent adverse events occurring in at least 2% of subjects in pooled phase III data Buvat et al. 2009; Kaufman et al. 2009; McMahon et al. 2010; Pryor et al. 2006.

DSM-IV TR, Diagnostic and Statistical Manual of Mental Disorders, 4th edition revised; IELT, intravaginal ejaculation latency time. It is the first medicine that has been formulated specifically to treat premature ejaculation. Even though the exact mechanism of action is not known, physicians suspect that it acts by inhibiting the serotonin transporter. The effects of 30 mg dapoxetine generally last for about 1 to 3 hours after taking the dose. However, the duration can vary depending on individual factors such as metabolism and overall health.